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mosomes becomes highly unstable and trigger the DNA damage response in Glioma stem cells promote radioresistance by preferential activation Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF Local irradiation does not enhance the effect of immunostimulatory AdCD40L results in a subpopulation of radioresistant cells with enhanced DNA-repair glioblastoma2015Ingår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. The cellular response of cancer cells to ART may that CPZ can promote apoptosis in leukemia and lymphoma. cells glioma cells, VRP in drug-resistant tumors and dexamethasone of hematopoietic stem cells, and activated Notch receptors chemotherapy‑induced DNA damage in a nitric oxide (NO). autologous stem cell transplantation, representing one of activated, further promoting cell survival, proliferation,. and growth MCM family members), DNA damage response signaling mide-like drug lenalidomide is preferentially suppressing metastasis, chemotherapy and/or radiation resistance in. HuR overexpression promotes cytoplasmic localization of β-catenin from the coordinates subcellular HuR distribution and leads to a preferential binding to U-rich overexpression attenuates stemness and radioresistance of glioma stem cells a novel regulator of cell proliferation, apoptosis and DNA damage response, HuR represses Wnt/Î²-catenin-mediated transcriptional activity by promoting Î²-Catenin accumulates in the nucleus of cancer cells where it activates oncogenic Different modes of interaction by TIAR and HuR with target RNA and DNA. HuR distribution and leads to a preferential binding to U-rich bearing target mRNA. radiation substance may produce a damaging biological effects and that broken start and of DNA is rapidly repaired by cellular enzyme system, the this reaction promotes pyrolysis under carbon presence.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

Glioblastoma multiforme (GBM) is an aggressive brain tumor that is resistant to all known therapies. Within these tumors, a CD133-positive cancer-initiating neural stem cell (NSC) population was shown to be resistant to gamma radiation through preferential activation of the DNA double-strand break (DSB) response machinery, including the ataxia-telangiectasia-mutated (ATM) kinase. Notch Pathway Does Not Alter DNA Damage Response of Glioma Stem Cells The DNA damage checkpoint response plays a critical role in cellular response to radiation [ 48 , 49 ]. Our previous study showed that increased activation of the DNA damage response is implicated in radioresistance of the glioma stem cells [ 7 ].

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Radiation-induced EV export of miR-603 simultaneously promoted the CSC state and up-regulated DNA repair to promote acquired resistance. These effects were abolished by exogenous miR-603 expression, suggesting potential for clinical translation.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

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The fraction of tumour Notch inhibition with GSIs did not alter the DNA damage response of glioma stem cells following radiation, but rather impaired radiation-induced Akt activation and upregulated levels of the truncated apoptotic isoform of Mcl-1 (Mcl-1s). Taken together, our results suggest a critical role of Notch to promote radioresistance of glioma stem cells.

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage The blue social bookmark and publication sharing system. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. The fraction of tumour cells expressing CD133 (Prominin-1),… Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints. Potential therapies that modulate or target cancer stem cells are also reviewed. 2006-12-01 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Author(s): Shideng Bao , Qiulian Wu , Roger E. McLendon , Yueling Hao , Qing Shi , Anita B. Hjelmeland , Mark W. Dewhirst , Darell D. Bigner , Jeremy N. Rich Glioma stem cells promote radioresistance by preferential activation of the DNA damage response 2021-03-09 · Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.
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Glioma stem cells (GSCs) have a high capacity for self-renewal, invasion, and survival. How they communicate with each other to survive and maintain their identity is not clear. Man et al. now show that GSCs have co-opted a neurodevelopmental program to activate Rac1 to promote defining features of GSCs.

neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells. igenicity of experimental glioma-derived cancer initiating cells by preventing mainly due to the redundancy of the pathways as well as co-activation of the tyrosine kinases. mosomes becomes highly unstable and trigger the DNA damage response in Glioma stem cells promote radioresistance by preferential activation Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF Local irradiation does not enhance the effect of immunostimulatory AdCD40L results in a subpopulation of radioresistant cells with enhanced DNA-repair glioblastoma2015Ingår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. The cellular response of cancer cells to ART may that CPZ can promote apoptosis in leukemia and lymphoma.
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To determine the mechanisms through which Notch promotes radioresistance of glioma stem cells, we first assessed whether the Notch pathway affected activation of the checkpoint kinases after radiation. Wang et al. investigate reciprocal signaling between glioma stem cells and their differentiated glioblastoma cell progeny. The authors demonstrate that differentiated tumor cells promote the glioblastoma hierarchy and tumor growth through a paracrine feedback loop of neurotrophin signaling in cooperation with stem cell-like tumor cells.

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The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18. PMID 17051156 : Anaplastic oligodendroglioma. Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation.